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What is Repeated Implantation Failure?

Repeated implantation failure refers to the failure torepeated implantation failure achieve pregnancy in an IVF cycle after transfer of at least three to four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under the age of 40 years.

Successful IVF, IVF-ICSI is good procedures, but still in some cases in spite of repeated attempts with good embryos the procedure is not successful.

Successful embryo implantation requires synchronous development and interaction between the embryo and the endometrium. Recurrent implantation failure causes a lot of mental and financial stress on the infertile couple. It is also very difficult for the treating doctor to explain the reasons for not being successful in spite of everything being right. RIF may be both of embryonic or uterine factors or both.

Repeated Implantation Failure (RIF) may be due to several causes:

  • Congenital uterine abnormalities, such as endometrial polyps, uterine fibroids,
  • adhesions, hydrosalpinges, endometriosis, etc.
  • Male factors such as severe oligoasthenozoo-spermia with increased sperm DNA fragmentation may also impact on the grading of the embryo.
  • Aneuploidy in embryos Metabolic disorders like uncontrolled diabetes, impaired thyroid function or prolactin level, etc. in the couple Thrombophilias or antiphospholipid syndrome Immunological factors.
  • Impaired endometrium:

  • Impaired endometrium can be a common cause of recurrent IVF failure. When morphologically good embryos are transferred, the question arises as to whether the problem is due to incompetent embryo or endometrium or both.
  • If the patient is young and there are morphologically good embryos then there is a greater chance that the problem lies with endometrium, either in terms of thickness, character, vascularity or immunology.
  • For successful implantation to occur, there are several chemical signals between the embryo and endometrium.
  • Maternal blood tests

    Clotting factors – Small clots in the blood have been identified as a possible cause for pregnancies failing to progress.T hese patients can be treated with aspirin or low dose heparin. Immunologic factors – High levels of uterine natural killer cells and auto-antibodies can also be the cause for RIF.